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Tramadol hydrochloride is a white, bitter, crystalline and odorless powder. It is readily soluble in water and ethanol and has a pKa of 9.41. Tramadol is what's more associated with a small risk of seizures (fits) and its use is contraindicated in people with a history of epilepsy. Tramadol case numbers significantly increased 165% during this time. For perspective, during the same period, DAWN uncovered nalbuphine (Nubain, what's more not CSA scheduled) in 118 cases, propoxyphene drug combinations (CSA Class IV) in more than 45,000 cases, codeine drug combinations (CSA Classes III & V) in about Fifty,000 cases, and hydrocodone drug combinations (CSA Class III) in around 128,000 cases.
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